The Il 23 Il 17 Pathway In Human Chronic Inflammatory Diseases New Insight From Genetics And Targeted Therapies Genes Immunity
IL23 can activate similar signaling pathways as does IL12, although IL23 induces weak activation of STAT4 Rather, IL23 is a potent activator of the STAT3 transcription factor IL23 is produced by numerous cell types including activated macrophages and DCs A team of French researchers may have found a new therapeutic target, the IL23/Th17 signaling cascade, to control tissue inflammation in patients with myasthenia gravis The study, " Il23/Th17 cell pathway A promising target to alleviate thymic inflammation maintenance in myasthenia gravis ," was published in the Journal of Autoimmunity
